During his trial in front of a United Federation of Planets court, Khan is asked why he does not resemble photographs of his namesake (in which the original Khan, as depicted by Ricardo Montalbán, is shown). Feeling bored, Khan begins to tell the background of his life, beginning as an orphaned child in New Delhi and following until he devises a plan to outwit his patron. Despite his intelligence and cleverness, Khan also has displayed an uncanny sense of brutality, marking him as a very dangerous man that the world is not ready for . . . but he doesn’t care.
The best thing that I think this comic has done is address the issue that a lot of fans had with the casting of Cumberbatch: why doesn’t he look as though he is of Indian descent? There are ways to explain this, such as that Khan’s face would be too recognizable and, thus, underwent facial reconstruction to hide his identity, but given the level of technology that is in the Star Trek universe, such an extreme feature might very well be unnecessary. The first issue doesn’t tell why he looks so different, but it does give a great background into just what and who he is as a person and how the Eugenics crisis came about.
We already know what the ultimate outcome for Khan and the Eugenics War is based on previously shown information, but seeing just how it all happened is something we haven’t been exposed to outside of non-canon novels. The step-by-step way in which we’re seeing the progression of his life and the world around him is quite entertaining, especially given how we know what the world view is supposed to be at the time the backstory takes place. It will be very interesting to see just what happens, how it relates to real-world events, and just how they tie in Cumberbatch's likeness with Montalbán’s.